(previously published by Churchill Livingstone) In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, second edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period. Features • Exhaustive: covers all the key pharmacologic and physiologic information on how each drug works at a molecular, cellular and organ level • Practical: gives all the important drug information an anesthetist needs – dose ranges, interactions with other drugs, toxicity, use in different patient groups • Relevant: the new section on Therapeutics of Clinical Practice tells the anesthetist how to select and use the right drugs in a wide range of day-to-day clinical scenarios Table of Contents Preface to the first edition Preface to the second edition Part I. Principles of Drug Action: 1. Pharmacodynamic principles of drug action 2. G protein coupled receptors 3. Other signalling pathways 4. Signal transduction mechanisms: ion channels 5. Principles of pharmacokinetics 6. Principles of drug transformation 7. Drug transport and transporters 8. Target controlled infusions and closed loop administration 9. Alternate routes of drug administration 10. Principles of pharmacogenetics 11. Pharmacodynamic drug interactions in anesthetic practice 12. Pharmacoeconomics Part II. Physiologic Substrates of Drug Action: 13. Sleep and consciousness 14. Synaptic transmission 15. Memory, learning and cognition 16. Mechanisms of pain transmission and transduction 17. Generation and propagation of action potentials 18. Neuromuscular junction 19. Vascular reactivity 20. Cardiac rhythm 21. Myocardial performance 22. Autonomic function 23. Physiology of immunity and inflammation Part III. Essential Drugs in Anesthetic Practice: 24. Mechanisms of anesthetic action 25. Pharmacokinetics of inhaled anesthetics 26. Clinical pharmacology of inhaled anesthetics 27. Pharmacokinetics of intravenous anesthetics 28. Clinical pharmacology of intravenous anesthetics 29. Benzodiazepines 30. α-2 Agonists and other sedatives and amnestics 31. Mechanisms of action of opioids 32. Pharmacokinetics of opioids 33. Clinical pharmacology of opioids 34. Nonsteroidal anti-inflammatory drugs 35. Other ion channel and receptor ligands for analgesia 36. Local anesthetics 37. Anticonvulsant and antipsychotic drugs 38. Neuromuscular blocking agents 39. Reversal drugs 40. Sympathomimetics and vasoconstrictors 41. Parasympathomimetic and parasympatholytic drugs 42. β-blockers and other adrenergic receptor antagonists 43. Antiarrhythmic agents 44. Positive inotropic drugs 45. Vasodilators (incl. ACE inhibitors and NO) 46. Calcium channel blockers 47. Bronchodilators 48. Pulmonary vasodilators 49. Drugs acting via the kidney 50. Fluids and electrolytes as pharmacologic agents 51. Corticosteroids and anti-inflammatory agents 52. Anti-rejection drugs and immunosuppressants 53. Antimotility and antisecretory agents 54. Antiemetics 55. Insulin and anti-hyperglycemic agents 56. Nutritional elements of management 57. Agents affecting coagulation and platelet function 58. Obstetrical adjuvants and obstetric pharmacology 59. Antimicrobial therapy Part IV. Clinical Application and Anesthesia Practice (Evidence Based, Rational Drug Selection, Management): 60. Pre-operative management 61. Induction of anesthesia 62. Maintenance and emergence from anesthesia 63. Management of sedation, analgesia and delirium 64. Post-operative analgesia 65. Control of blood pressure and vascular tone 66. Cardiac protection and pharmacologic management of myocardial ischemia 67. Management of patients with chronic alcohol or drug use 68. Drug allergy and treatment 69. Special populations – pediatric 70. Special populations – geriatric 71. Emerging concepts: neuroprotection and neurotoxicity Index.
