Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists. - Reviews diseases involving interactions between the nervous and immunological systems - a complex area: text explains basic science in a clinician-friendly manner - Coverage includes major areas of neurology, e.g. multiple sclerosis, neurological infections, trauma - therefore wide readership potential - Therapeutic management of inflammation covered - practical clinical advice on how to manage inflammatory conditions - Rehabilitation aspects included - great interest in how modulation of inflammation can stimulate neurological function and aid recovery Contents Preface; Part I. Interactions Between the Immune and Nervous Systems: 1. Effectors and determinants of the innate and adaptive immune responses Edgar Meinl and Hartmut Wekerle; 2. Microglia: protective and pathogenic mediators Bevyn Jarrott and Karina Apricò; 3. The role of dendritic cells in neuroinflammation Heather Donaghy, Edwina J. Wright and Anthony L. Cunningham; 4. Negotiating the brain barriers: access of immune cells and pathogens into the CNS Britta Engelghardt; Part II. Autoimmunity: 5. Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders Shaunu F. Roemer and Claudia F. Lucchinetti; 6. Multiple sclerosis: neuroimmune crosstalk in acute and progressive stages of the disease Martin Kerschensteiner and Reinhard Hohlfeld; 7. CD8+ T Cell-mediated autoimmune diseases in the CNS Lisa Walter and Matthew L. Albert; 8. Acute disseminated encephalomyelitis: determinants and manifestations Eppie M. Yiu and Andrew J. Kornberg; 9. Primary angiitis of the CNS and its mimics Tina Chadha, George F. Duna and Leonard H. Calabrese; Part III. Microbiological and Traumatic Challenges to the CNS: 10. Acute viral encephalitis: role of the immune system in viral clearance from the CNS and in the generation of pathology David N. Irani and Natalie Prow; 11. Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology Carolyn F. Orr and Bruce J. Brew; 12. Brain inflammation during bacterial meningitis Trine H. Mogensen and Lars Østergaard; 13. Parasitic infections of the brain: malaria and beyond Stephen J. Rogerson and Danny A. Milner Jr; 14. Role of the inflammatory process in traumatic brain damage Cristina Morganti-Kossmann, Laveniya Satgunaseelan, Nicole Bye, Phuong Nguyen and Thomas Kossmann; Part IV. Therapy: 15. HIV-associated neurocognitive disorders: clinical features and therapeutic challenges Nicoline Schiess and Justin C. McArthur; 16. Role of immunomodulation in management of infections of the CNS Miles H. Beaman; 17. Neuroinflammation: an emerging therapeutic target in neurological disease Joseph M. Antony and Christopher Power; Index. Contributors Edgar Meinl, Hartmut Wekerle, Bevyn Jarrott, Karina Apricò, Heather Donaghy, Edwina J. Wright, Anthony L. Cunningham, Britta Engelghardt, Shaunu F. Roemer, Claudia F. Lucchinetti, Martin Kerschensteiner, Reinhard Hohlfeld, Lisa Walter, Matthew L. Albert, Eppie M. Yiu, Andrew J. Kornberg, Tina Chadha, George F. Duna, Leonard H. Calabrese, David N. Irani, Natalie Prow, Carolyn F. Orr, Bruce J. Brew, Trine H. Mogensen, Lars Østergaard, Stephen J. Rogerson, Danny A. Milner Jr, Cristina Morganti-Kossmann, Laveniya Satgunaseelan, Nicole Bye, Phuong Nguyen, Thomas Kossmann, Nicoline Schiess, Justin C. McArthur, Miles H. Beaman, Joseph M. Antony, Christopher Power
