Breast

Breast pathology is arguably considered the most challenging and controversial area of diagnostic pathology. Many gradations of normal, pre-cancerous, and cancerous conditions are often indistinguishable, making a clear-cut diagnosis very difficult and often a cause for intense debate. This latest book in the Cambridge Illustrated Surgical Pathology series comprehensively covers all methods utilized by pathologists to accurately diagnose diseases affecting the breast. Malignant tumors are the predominant focus, but a full spectrum of inflammatory disorders and hyperplasias is also covered in detail, and the book uniquely shows the progression of disease states from incipient to advanced. Findings are diagnosed not only through the light microscope but also through genetic, molecular, and immunologic modalities; the text additionally includes the interpretation of cytologic specimens as an important diagnostic modality in breast pathology. The book is highly illustrated, with more than 300 color photomicrographs, and accompanied by a CD-ROM of all images. - Comprehensively covers all methods utilized by pathologists to diagnose diseases affecting the breast - Exclusive to diagnostic and clinical criteria, with unique orientation showing progression from incipient to advanced disease states - Illustrated with over 300 color photomicrographs and accompanied by a CD-ROM of all images CONTENTS 1. Normal Histology and Metaplasias Anatomy and Histology Metaplasias 2. Adenosis, Sclerosing Lesions, and Miscellaneous Benign Entities Adenosis and Sclerosing Adenosis Microglandular Adenosis Radial Scar/Complex Sclerosing Lesions Collagenous Spherulosis 3. Reactive and Inflammatory Lesions Mastitis Duct Ectasia Fat Necrosis Radiation Atypia Diabetic Mastopathy Gynecomastia 4. Fibroepithelial Lesions Fibroadenoma Juvenile Fibroadenoma Phyllodes Tumor 5. Nipple Lesions Paget's Disease of the Nipple Nipple Adenoma Syringomatous Adenoma 6. Papillary Lesions General Clinical and Radiographic Features Intraductal Papilloma Atypical Ductal Hyperplasia and Ductal Carcinoma in situ Involving a Papilloma Intraductal Papillary Carcinoma and Solid Papillary Carcinoma Encysted/Encapsulated Papillary Carcinoma Management of Papillary Lesions 7. Benign Stromal Lesions Pseudoangiomatous Stromal Hyperplasia Hemangiomas Hamartoma and Myoid Hamartoma Myofibroblastoma Fibromatosis Granular Cell Tumor 8. Lobular Neoplasia (Noninvasive) Clinical Features Macroscopic and Microscopic Features Differential Diagnosis Treatment and Prognosis 9. Ductal Neoplasia Ductal Hyperplasia and Atypical Ductal Hyperplasia Ductal Carcinoma in situ Flat Epithelial Atypia 10. Invasive Carcinoma, Special Types Introduction Invasive Lobular Carcinoma Tubular Carcinoma Invasive Cribriform Carcinoma Tubulolobular Carcinoma Mucinous Carcinoma Medullary Carcinoma Invasive Papillary Carcinoma Invasive Micropapillary Carcinoma Secretory Carcinoma Adenoid Cystic Carcinoma Rare Histologic Patterns of Invasive Carcinoma Invasive Carcinoma with Apocrine Features Invasive Carcinomas with Clear Cell (Glycogen-Rich and Lipid-Rich) Features Invasive Carcinoma with Signet-Ring Cell Features Invasive Carcinomas with Neuroendocrine Features 11. Invasive Carcinoma, No Special Type General Features and Histology/Grading Prognostic and Predictive Factors Invasive Carcinoma with Basal Phenotype 12. Metaplastic Carcinoma and Sarcoma Metaplastic Carcinoma Spindle Cell Carcinoma Squamous Cell Carcinoma Metaplastic Carcinoma with Osteochondroid Differentiation Sarcoma 13. Cytology of the Breast Clinical Indications and Limitations Terminology/Reporting Sample Preparation Fibroepithelial Lesions Papillary Lesions Proliferative Epithelial Lesions, Including Those with "Atypia" Carcinoma Metaplastic, Mesenchymal, and Spindle Cell Lesions Newer Technologies Hormone Receptor and HER-2 Studies in Breast Cancer Diagnostics Ductal Lavage Cytology and Nipple Fluid Analysis Use of Imprint Cytology (Touch Prep) in Intraoperative Consultation: Margin Assessment and Sentinel Node Evaluation Index