Blood Disorders in the Elderly

Lodovico Balducci ( H. Lee Moffitt Cancer Center & Research Institute, Florida) - William Ershler ( Institute for Advanced Studies in Aging and Geriatric Medicine, Washington DC) - Giovanni De Gaetano ( Catholic University, Campobasso) The developed world has an increasingly aging population, with approximately 10% of the population aged over 65 years. As the incidence and prevalence of blood disorders increases with age, these conditions are a heavy burden on healthcare systems. Blood Disorders in the Elderly will provide hematologists, geriatricians and all clinicians involved in the care of patients with blood disorders with clear clinical advice on the diagnosis and management of these conditions. The introductory section reviews epidemiology of aging and anemia and provides a comprehensive approach to the management of cancer in the aging patient. This is followed by a full discussion of hemopoiesis and changes it undergoes in aging. The remaining sections cover the diagnosis and management of all major disorders: anemia, malignancy, coagulation and platelet disorders and hemophilia. A detailed chapter on antithrombotic therapies is also included. - Comprehensive coverage of all blood disorders from international experts in hematology and geriatric medicine - Introduction sections on epidemiology and changes in hemopoiesis with aging - Contains a 16 page color plate section to aid diagnosis of disorders Contents Introduction; Part I. Epidemiology: 1. Epidemiology of aging Lodovico Balducci and William B. Ershler; 2. Epidemiology of anemia: older adults Kushang V. Patel and Jack M. Guralnik; 3. Cancer in the older person: a comprehensive approach Oscar A. Cepeda, Julie K. Gammack and John E. Morley; 4. From fitness to frailty: toward a nosologic classification of the older aged person Lodovico Balducci and Claudia Beghe; Part II. Hemopoiesis: 5. Stem cell exhaustion and aging Gary Van Zant; 6. Hemopoietic micro-environment and age David N. Haylock and Susan K. Nilsson; 7. Replicative senescence, aging, and cancer Rita Effros; 8. Qualitative changes of hemopoiesis France Laurencet and Gilbert Zulian; 9. Aging and hemopoietic stress Lodovico Balducci and Cheryl Hardy; 10. Immunoglobulin response and aging Yuping Deng and Stefan Gravenstein; 11. Biological and clinical significance of monoclonal gammopathy Arati V. Rao and Harvey J. Cohen; Part III. Anemia of Aging: 12. Erythropoietin and aging Andrew S. Aartz; 13. Iron and aging E. Nemeth and Tomas Ganz; 14. Prevalence and mechanism of B12 deficiency Sally P. Stabler; 15. The consequences of anemia Luigi Ferrucci and Dan L. Longo; 16. The pathogenesis of late-life anemia Bindu Kanapuru and William B. Ershler; 17. Treatment of late-life anemia William B. Ershler; Part IV. Hematological Malignancies and Aging: 18. Cancer chemotherapy in the older person Lodovico Balducci; 19. Acute myeloid leukemia in the elderly Magda Elkabani and Jeffrey Lancet; 20. Acute lymphoblastic leukemia in elderly patients: diagnosis and therapy Salvatore Bruno, Femina Mazzella and Oscar Ballester; 21. Multiple myeloma Todd J. Alekshun and Melissa Alsina; 22. Non-Hodgkin lymphoma Nicole Jacobi and Bruce A. Peterson; 23. Unusual lymphomas in the elderly Youssef Gamal, Samuel Kerr and Thomas P. Loughran; 24. Chronic lymphocytic leukemia in the elderly Alexander S. D. Spiers; 25. Polycythemia vera and idiopathic myelofibrosis in the elderly Jerry L. Spivak; Part V. Disorders of Hemostasis in the Elderly: 26. Acquired hemophilia in the elderly F. Baudo and F. de Cataldo; 27. Blood coagulation and aging Jozef Vermylen and Marc F. Hoylaerts; 28. Platelet disorders in the elderly Laura Terranova, Giancarla Gerli and Marco Cattaneo; 29. Gene-environment interactions and vascular risk in the elderly Daniela Mari; 30. Antithrombotic therapy: guidelines for the elderly Chiara Cerletti, H. J. Schunemann and Giovanni de Gaetano.