Questions regarding the nature and appropriate management of cavernous malformation (CM) have clouded researchers and those faced with making clinical decisions for several decades. CMs may be seen as an incidental finding on MRI studies, or they may present with symptoms, such as seizures or intracranial hemorrhage, often causing severe neurologic deficit. Cavernous Malformations of the Nervous System provides a comprehensive and authoritative review of the current practice in diagnosis and management of these cerebrovascular disorders. Emphasis has been laid on the understanding of basic sciences with chapters committed to understanding of CCM1, 2 and 3 genes and their role in CCM biology, as well as clinical genetics. Controversial topics which continue to pose treatment challenges such as safety of anticoagulation and prophylactic management during pregnancy are also discussed. This book will be of interest to basic science researchers, neurosurgeons and vascular neurologists both in academic institutions and private practice. Features • Presents a comprehensive reference source to the molecular biology and genetics of cavernomas by leading experts in the field • Provides essential information about radiological diagnosis and natural history • Addresses the challenges and controversies regarding treatment and discusses treatment options Daniele Rigamonti, The Johns Hopkins University Table of Contents Preface Part I. Basic Sciences: 1. Pathology of cavernous malformations Sachin Batra, Barbara Crain, Rachel Engelmann, Joaquin Camara-Quintana and Daniele Rigamonti 2. Epidemiology and natural history of cavernous malformations Rachel Engelmann, Sachin Batra, Angela Li, Joaquin Camara-Quintana and Daniele Rigamonti 3. Familial cavernous malformations: a historical survey Leslie Morrison 4. Clinical and molecular genetics of cerebral cavernous malformations Xavier Ayrignac and Elisabeth Tournier-Lasserve 5. Molecular biology of cerebral cavernous malformation Jun Zhang 6. Cavernous malformations and radiation Eugenio Pozzati and Nicola Acciarri 7. Neuroimaging of cavernous malformations Doris D. M. Lin and Wael Abdalla 8. Clinical features and medical management of cavernous malformations Michel J. Berg and Tegan Vay Part II. Clinical Features, Imaging and Diagnostic Work-up: 9. Hemorrhage: new and recurrent Colin B. Josephson and Rustam Al-Shahi Salman 10. Medical management of seizures and the presurgical evaluation of medically intractable epilepsy Gregory K. Bergey Part III. Therapy: 11. The pros and cons of conservative and surgical treatment of cavernous malformations Pablo F. Recinos, Sheng-Fu Larry Lo, Christopher Wallace and Daniele Rigamonti 12. Surgical treatment of cavernous malformations associated with epilepsy Mahua Dey and Issam Awad 13. Surgery of spinal cavernous malformations M. Yashar S. Kalani and Robert F. Spetzler 14. Surgical treatment of cavernous malformations in children Edward R. Smith and R. Michael Scott 15. Resection of cavernous malformations of the brainstem Helmut Bertalanffy, Jan-Karl Burkhardt, Ralf Alfons Kockro, Johannes Sarnthein and Oliver Bozinov 16. Principles for managing cavernous malformations in eloquent locations Uğur Türe and Ahmet Hilmi Kaya 17. Radiosurgery of cavernous malformations: the Pittsburgh experience Douglas Kondziolka, L. Dade Lunsford, Hideyuki Kano and John C. Flickinger Part IV. Basic Aspects: 18. Genetic counselling Leslie Morrison 19. Special problems in cavernous malformations Richard Leigh and Robert J. Wityk Index.