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Pain is one of the most common symptoms of neurological disease and its appropriate management is essential to the effective care of patients. Neurological disorders differ in their specific pain phenotype, mechanisms and therapy. Case Studies in Neurological Pain addresses the specific pain issues, treatment and pathophysiology in patients with a wide spectrum of neurological disease. Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning – all desirable generic skills for health care professionals. Presenting real-life cases – covering conditions including diabetic and idiopathic polyneuropathies, focal neuropathies, multiple sclerosis and headache disorders – this book provides neurologists, neurosurgeons, pain clinic specialists and primary care physicians with an understanding of problems encountered in neurological practice. There are also chapters on mechanisms of neurological pain and new treatment guidelines. Features • Includes recommended treatment plans to aid quick and accurate treatment • Real-life cases facilitate understanding of the patient's problems more accurately than data from clinical trials • Discusses mechanisms of pain and therapeutic challenges to guide researchers and industry in their approach to new therapies Table of Contents Preface Part I. The Biology of Neuropathic Pain: 1. Mechanisms of neuropathic pain Part II. Focal, or Localized Neuropathies: 2. Pain in carpal tunnel syndrome 3. Pain and cervical radiculopathy 4. Pain and diabetic lumbosacral plexopathy 5. Pain and meralgia paraesthetica 6. Pain and lyme radiculopathy (Borrelia-associated radiculitis) 7. Neuralgic amyotrophy 8. Painful radiculopathy associated with herpes zoster infection Part III. Generalized neuropathies or polyneuropathies: 9. Pain and chronic inflammatory demyelinating polyneuropathy 10. Pain and diabetic polyneuropathy (DPN) 11. Painful idiopathic polyneuropathy 12. Pain in vasculitic neuropathy 13. Painful polyneuropathy associated with anti-MAG autoantibodies 14. Painful polyneuropathy associated with inherited amyloidosis 15. Small fiber neuropathy in sarcoidosis 16. Pain and small fiber polyneuropathy in Fabry disease Part IV. Other Neuromuscular and Neurological Disorders: 17. Pain and proximal myotonic myopathy (DM2) 18. Complex regional pain syndrome 19. Pain and polymyalgia rheumatica 20. Phantom pain Part V. CNS Disorders: 21. Pain in Parkinson's disease 22. Pain associated with amyotrophic lateral sclerosis (ALS) 23. Pain in Brown–Séquard syndrome 24. Pain in syringomyelia 25. Central pain with thalamic infarct 26. Pain in multiple sclerosis Part VI. Headache Disorders: 27. Chronic migraine 28. Cluster headache 29. Paroxysmal hemicrania 30. Trigeminal neuralgia 31. Headache and acute cerebral ischemia Part VII. Treatment: 32. Therapeutics in neuropathic pain Index.
