Clinical Radiation Oncology

Contents

Dedication ix

Preface xi

Contributors xiii

Section 1 Scientific Foundations 1
Section Editor:William Small Jr.

1 Basic Concepts of Clinical Radiation Oncology 3
Hannah Yoon, Karan Shah,William Small Jr,Minesh P.Mehta and John P. Hayes

2 Radiation Biology for Radiation Oncologists 15
Timothy A. Chan, Boris Hristov and Simon N. Powell

3 Treatment Planning 62
George T.Y. Chen and Jong H. Kung

4 Image-Guided Radiation Therapy 83
Monique Youl, Kristy K. Brock and Laura A. Dawson

5 A Guide to Understanding Statistics in Radiation Oncology 99
Kathryn Winter

6 Use of Protons for Radiation Therapy 115
Mark Pankuch, Nasiruddin Mohammed, Draik Hecksel, Steve Laub, Sean Boyer and William F. Hartsell

7 Principles of Palliative Radiation Therapy 141
Randy L. Wei, Bo A. Wan, Edward Chowand Stephen Lutz

8 Patient Safety and Quality: Management for the Radiation Oncologist 158
Fiori Alite and Abhishek A. Solanki

Section 2 Cancers of the Head and Neck 175
Section Editor: Min Yao

9 Carcinoma of the Oral Cavity 177
Keith Unger, Felix Ho, James Melotek and Nancy Lee

10 Oropharyngeal Cancer 202
Charles Woods, Mitchell Machtay and Min Yao

11 Larynx and Hypopharynx 227
Changhu Chen

12 Carcinoma of the Nasopharynx 248
Keith Unger, Felix Ho, James Melotek and Nancy Lee

13 Carcinoma of the Paranasal Sinuses and Nasal Cavity 269
Farzan Siddiqui, Nicholas Galanopoulos and Min Yao

14 Salivary Gland Carcinomas 288
Allen M. Chen

15 Cervical Nodes with Unknown Primary Carcinomas 300
Min Yao, Pierre Lavertu and Mitchell Machtay

16 Temporal Bone Tumors 313
Allen M. Chen

17 Thyroid Cancer 318
Roi Dagan and Robert J. Amdur

18 Head and Neck Radiation Therapy Sequelae and Late Complications and the Role of IMRT 335
Xiaoshen Wang and Avraham Eisbruch

Section 3 Cancer of the Intrathorax 349
Section Editor: Minesh P. Mehta

19 Lung Cancer 351
Deepak Khuntia, Pranshu Mohindra and Minesh P. Mehta

20 Carcinoma of the Esophagus 385
Grace J. Kim and Mohan Suntharalingam

Section 4 Gastrointestinal Malignancies 397
Section Editor: Christopher G.Willett

21 Gastric Cancer 399
Joanna Y. Chin and Theodore S. Hong

22 Pancreatic Cancer 409
Manisha Palta, Christopher G.Willett and Brian G. Czito

23 Colon Cancer 429
Jennifer Y. Wo

24 Rectal Cancer 438
Jennifer Y. Wo

25 Anal Cancer 466
Brian G. Czito, Manisha Palta and Christopher G. Willett

Section 5 Genitourinary Malignancies 481
Section Editor: Jason A. Efstathiou

26 Bladder Cancer 483
Phillip J. Gray,William U. Shipley and Jason A. Efstathiou

27 Prostate Cancer 497
Abhishek A. Solanki, Rebecca I. Hartman, Phillip J. Gray, Brent S. Rose, Jonathan J. Paly, Kent W. Mouw and Jason A. Efstathiou

28 Carcinoma of the Upper Urinary Tract 531
Anthony L. Zietman, Jonathan J. Paly and Jason A. Efstathiou

29 Testicular Cancer 539
Jonathan J. Paly and Jason A. Efstathiou

30 Penile Cancer 549
Kent W. Mouw, Anthony L. Zietman and Jason A. Efstathiou

Section 6  Gynecological Malignancies 557
Section Editor:William Small Jr.

31 Endometrium 559
Ann Klopp and Patricia Eifel

32 Vulva 576
Kanokpis Townamchai, Caitlin Newhouse and Akila N. Viswanathan

33 Ovary 597
Charles A. Kunos

34 Vagina 618
Charles A. Kunos

35 Cervix 631
Charles A. Kunos

Section 7 Miscellaneous Sites 673
Section Editor:William Small, Jr

36 Cancer of the Skin 675
Justin Lee, Elizabeth Barnes, May Tsao and Phillip Devlin

37 Cancer of the Breast 694
Jonathan B. Strauss, Monica Morrow and William Small Jr

38 Soft-Tissue Sarcomas 739
Jonathan B. Ashman and Kaled M. Alektiar

39 Tumors of the Central Nervous System 757
Phillip J. Gray, Jay S. Loeffler and Helen A. Shih

40 The Lymphomas 775
Caitlin Costello, Loren K. Mell and Parag Sanghvi

41 Pediatric Tumors 805
Shannon M. MacDonald, Torunn I. Yock, Nancy J. Tarbell and Tamara Z. Vern-Gross

Index 845

 William Small Jr, MD, Professor of Radiation Oncology, Professor and Chair of the Department of Radiation Oncology, Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA

Associate Editors
Nancy J. Tarbell, MD, Dean for Academic and Clinical Affairs and the C.C. Wang Professor of Radiation Oncology, Harvard Medical School, MA, USA

Min Yao, MD, PhD, Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA

Section Editors
Minesh Mehta, MD, Jason A. Efstathiou, MD, and Chis Willet, MD

Dr Chiu-Chen Wang, Founding Editor of Clinical Radiation Oncology

Edited for two successful editions (1988 and 2000) by the eminent physician Dr Chiu-Chen Wang, this book was designed to offer highly practical, application-based comprehensive overview of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. Dr Wang, widely known as "C.C." and well known for his "???skilled and no-nonsense methods of dealing with the various types of major organ cancers," passed away in 2005. He was a highly acclaimed leader in the field of radiation oncology based at Harvard Medical School, which established the "C.C. Wang Professorship in Radiation Oncology."