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Immunology at a Glance provides a user-friendly overview of the body’s defence mechanisms. Ideal from day one of a medical, biomedical or life science course, the text begins with a basic overview of both adaptive and innate immunity, before progressing to applied immunological concepts, which look at what happens when things go wrong, and how, in clinical medicine, each body system can be affected by immunity. Each double-page spread corresponds to a typical lecture and diagrammatically summarises core concepts in immunology, through accessible schematic diagrams on left-hand pages, with key points concisely summarised on the right-hand page. There are also self-assessment essay questions so you can test your knowledge. New for this 10th edition: Thoroughly updated and reorganised chapters offer greater clarity and easier understanding for those new to the subject New chapters on cytokine receptors and ‘Immunology in the Laboratory’ A completely re-written section on autoimmunity A brand new companion website featuring self-assessment questions and PowerPoint slides of images from the book, ideal for teaching and revision at www.ataglanceseries.com/immunology Immunology at a Glance is the ideal companion for anyone about to start a new course in immunology and will appeal to medical and biomedical science students. Perfect for exam preparation, it provides the concepts and frameworks you need to succeed in your exam. CONTENTS Preface Acknowledgements Note on the ninth edition How to use this book Further reading Immunity 1 The scope of immunology 2 Innate and adaptive immune mechanisms 3 Recognition and receptors: the keys to immunity 4 Cells involved in immunity: the haemopoietic system Innate immunity 5 Receptors of the innate immune system 6 Complement 7 Acute inflammation 8 Phagocytic cells and the reticuloendothelial system 9 Phagocytosis Adaptive immunity (i) The molecular basis 10 Evolution of recognition molecules: the immunoglobulin superfamily 11 The major histocompatibility complex 12 The T-cell receptor 13 Antibody diversification and synthesis 14 Antibody structure and function (ii) The cellular basis 15 Lymphocytes 16 Primary lymphoid organs and lymphopoiesis 17 Secondary lymphoid organs and lymphocyte traffic (iii) The adaptive immune response 18 Antigen processing and presentation 19 The antibody response 20 Antigen–antibody interaction and immune complexes 21 Cell-mediated immune responses (iv) Regulation 22 Tolerance 23 Cell communication and cytokines 24 The cytokine network 25 Immunity, hormones and the brain Potentially useful immunity 26 Antimicrobial immunity: a general scheme 27 Immunity to viruses 28 HIV and AIDS 29 Immunity to bacteria 30 Immunity to fungi and ectoparasites 31 Immunity to protozoa 32 Immunity to worms Undesirable effects of immunity 33 Immunodeficiency 34 Harmful immunity: a general scheme 35 Allergy and anaphylaxis 36 Immune complexes, complement and disease 37 Chronic and cell-mediated inflammation 38 Autoimmune disease 39 Transplant rejection Altered immunity 40 Immunosuppression 41 Immunostimulation and vaccination Immunity in health and disease 42 Cancer immunology 43 Immunity and clinical medicine 44 Investigating immunity 45 Immunology in the laboratory 46 Out of the past:: evolution of immune mechanisms 47 Into the future: immunology in the age of genomics Self-assessment Self-assessment questions Answers Appendices Appendix I: Comparative sizes and molecular weights Appendix II: Landmarks in the history of immunology and some unsolved problems Appendix III: CD classification Index