This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.
Presents a clinically oriented guide to the diseases caused by neurodegeneration
Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases
Edited by globally leading authorities on the subject, and written by expert contributing authors
Contents
List of Contributors
Preface
Dedication
Chapter 1: Pathology of Brain Aging
Janna H. Neltner and Peter T. Nelson
Chapter 2: Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies
Michel Goedert
Chapter 3: Prion Degeneration
James A. Mastrianni
Chapter 4: Excitotoxicity
Mark P. Mattson
Chapter 5: Aetiology and Pathogenesis of Parkinson Disease
Ruth-Mary deSouza and Anthony H.V. Schapira
Chapter 6: Parkinson’s Disease: Treatment Options – Surgical Therapy
Travis S. Tierney and Andres M. Lozano
Chapter 7: Multiple System Atrophy (MSA): Clinical, Genetics and Neuropathology
Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden and Owen A. Ross
Chapter 8: Progressive Supranuclear Palsy
Huw R. Morris
Chapter 9: Dementia with Lewy Bodies
Rodolfo Savica and David S. Knopman
Chapter 10: Corticobasal Degeneration
Keith A. Josephs
Chapter 11: Alzheimer’s Disease
Qurat ul Ain Khan and Neill R. Graff-Radford
Chapter 12: Frontotemporal Dementia
Christian Wider, Barbara Jasinska-Myga and Zbigniew K. Wszolek
Chapter 13: Prion Diseases and Other Rapidly Progressive Dementias
Eric Eggenberger and Daniel L. Murman
Chapter 14: ALS and PLS
Kevin B. Boylan, Mark A. Ross and Eric J. Sorenson
Chapter 15: Hereditary Spastic Paraplegia
Pawel P. Liberski and Craig Blackstone
Chapter 16: Spinal Muscular Atrophy
Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles and Charlotte J. Sumner
Chapter 17: Spinal and Bulbar Muscular Atrophy (Kennedy Disease)
Erich Peter Bosch
Chapter 18: Optic Neuropathies
Desmond Kidd
Chapter 19: Peripheral Nerve Neuropathies Including CMT Disease
Amelie Pandraud and Henry Houlden
Chapter 20: Axonal Loss and Neurodegeneration in Multiple Sclerosis
Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda and Bruce D. Trapp
Chapter 21: Neurodegeneration: Huntington’s Disease and Other Choreas
Salman Haider, Edward Wild and Sarah J. Tabrizi
Chapter 22: Spinocerebellar Ataxias
H. Brent Clark and Harry T. Orr
Chapter 23: Ataxia Telangiectasia
Malcolm Taylor
Chapter 24: Niemann-Pick Disease
Marc C. Patterson
Chapter 25: X-linked Adrenoleukodystrophy
Deborah L. Renaud
Chapter 26: Neurodegeneration with Brain Iron Accumulation, Wilson Disease, Manganism
Alisdair McNeill
Index
