An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)-a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain-spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain-joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain-general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis. David T. Felson, Hans-Georg Schaible CONTENTS PART I: THE NEUROSCIENCE OF ARTICULAR PAIN. 1. Schaible: Spinal mechanisms of joint pain. 2. Grubb: Peripheral mechanisms of joint pain. 3. Henry: Experimental Models for the study of osteoarthritic pain. 4. Kidd et al: Inflammatory mediators and nociception in arthritis. 5. McCabe et al: Phantoms in rheumatology. 6. Mantyh and Hunt: Neuronal mechanisms of bone cancer pain. 7. Shenker, Blake et al: Neuronal mechanisms of symmetry in clinical disease. PART II: OSTEOARTHRITIS AND PAIN. 8. Herzog et al: Joint mechanics in OA. 9. Brandt: Neuromuscular aspects of OA. 10. Simkin: Bone pain and pressure in OA joints. 11. Conaghan: Structural correlates of OA pain: lessons from MRI imaging. 12. Ordeberg: Is there evidence of Allodynia in OA? 13. Creamer: The clinical presentation of pain in OA. PART III: TREATMENT OF OSTEOARTHRITIC PAIN. 14. Felson: General Approaches to Treatment of OA Pain: modulating inflammation; inhibting pain receptors, modifying biomechanics. 15. Neogi: Treatments targeting pain receptors in OA. 16. Bennell: Treatments targeting biomechanical abnormalities in OA: braces, splints and surgeries. 17. Felson: Treatments targeting inflammation in OA pain.