# A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. # International list of contributors including the leading workers in the field. # Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care. Edited by Wolfgang Grisold, Head of Department, Neurologic Department and LBI for Neuro-Oncology, Kaiser Franz Josef Hospital, Vienna, Austria and Riccardo Soffietti, Department of Neuroscience, Neuro-Oncology, University of Torino, Italy (Series Editors: Aminoff, Boller and Swaab) Table of Contents: SECTION 1 Basic principles 1. Epidemiology of central nervous system tumours 2. Molecular biology of brain tumors 3. Angiogenesis and invasion in cancer 4. Immunology of brain tumors 5. Blood brain barrier and brain edema 6. Stem cells in gliomas SECTION 2 Diagnostic tools 7. Diagnostic neuropathology of tumors of the central nervous system 8. Neuroimaging 9. Functional imaging in brain surgery 10. Imaging brain tumors with PET, SPECT, ultrasound 11. CSF and laboratory analysis (tumor markers) 12. Electrophysiology and intraoperative neurophysiological monitoring 13. Evaluation and monitoring of peripheral nerve function 14. Evaluation of cognitive functions and quality of life SECTION 3 Principles of Therapy 15. Principles of brain tumor surgery 16. Radiotherapy 17. Chemotherapy with cytotoxic and cytostatic agents in brain cancer 18. Molecularly targeted therapy in Neuro-oncology 19. Inhibiting angiogenesis in malignant gliomas 20. Immunotherapy of brain tumors 21. Gene therapy 22. Chemotherapy for brain tumors with polymer drug delivery 23. Convection-enhanced delivery of therapeutic agents into the brain 24. Management of cognitive deficits and mood disturbance 25. Steroids and brain tumors 26. Seizure control in brain tumours 27. Cancer pain management and palliative care 28. Clinical trials in Neuro-oncology
