A volume in the Handbook of Clinical Neurology series on bacterial infections. Karen L. Roos , Indiana University School of Medicine, Indianapolis, IN, USA and Allan R. Tunkel , Chair, Department of Medicine, Monmouth Medical Center, Long Branch, NJ, USA Table of Contents: Pathogenesis and pathophysiology of bacterial CNS infections. Principles of antimicrobial therapy. Lumbar puncture and cerebrospinal fluid analysis. Bacterial meningitis. Brain abscess. Cranial epidural abscess and subdural empyema. Spinal epidural abcess and subdural empyema. Suppurative intracranial thrombophlebitis. Infections of the central nervous system in the neurosurgical patient. Rickettsial and Ehrlichial infections. Tuberculosis and atypical Mycobacterial Infections. Spirochetal infections. Neurological complications of bacterial endocarditis. Whipple's disease of the central nervous system. Neuroimaging of central nervous system Infections. Toxin-mediated syndromes of the nervous system.