A volume in the Handbook of Clinical Neurology series (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) on neuromuscular junction disorders, covering the basic science of the neuromuscular junction, clinical presentations and therapy. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care CONTENTS The most vulnerable synapse: historic aspects of neuromuscular junction disorders. Reliability of neuromuscular transmission and how it is maintained. The neuromuscular junction. Electromyographic aspects of neuromuscular junction disorders. The immunopathogenesis of myasthenia gravis. Autoantibodies in different forms of myasthenia gravis and in the Lambert-Eaton syndrome. Clinical features of myasthenia gravis. Therapy of myasthenia gravis. The Lambert-Eaton myasthenic syndrome. Congenital myasthenic syndromes. Botulism. Neurotoxicology of neuromuscular transmission. Organophosphate and carbamate poisoning. Peripheral nerve hyperexcitability and the neuromuscular junction.