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This book provides a definitive reference work on the developing brain, from conception through the first year of life. Its purpose is to provide the range of specialists involved in the management of the fetus and the neonate with the latest information on the developmental neurology and pathology of the developing central nervous system, so that they can provide prompt and informed treatment of neurological disability - the most feared complication of pregnancy and the early months of the life of the newborn child. CONTENTS SECTION I Structural Development of the CNS 1. Genetic and Epigenetic Control of the Early Brain Development 2. Early Embryonic and Fetal Development 3. The Emergence of Consciousness 4. Ultrasound Assessment of Normal Fetal Brain Development 5. MR Imaging of the Fetal Brain 6. Imaging the Neonatal Brain 7. Insights Using New MR Techniques SECTION II Functional Assessment of CNS Development 8. Functional Assessment of the Fetal CNS 9. The Fetal Senses 10. Clinical Assessment of the Infant Nervous System 11. Doppler Assessment of the Fetal and Neonatal Brain 12. Measurement of CBF and Metabolism of the Developing Brain 13. Neonatal Neurophysiology SECTION III Anomalies 14. Congenital Structural Defects of the Brain 15. Genetics of Neurodevelopmental Anomalies 16. Functional Effects of Drugs and Other Chemicals on the Developing Brain 17. Antenatal Screening for Neurologic Disorders 18. Antenatal Assessment of CNS Anomalies, including NTDs: Abdominal Ultrasound 19. Transvaginal Fetal Neuroscan 20. Epidemiology and Prevention of NTDs SECTION IV Hemorrhagic and Ischemic Lesions 21. Fetal Cerebral Pathology of Hypoxic-Ischemic Origins 22. Multiple Pregnancy and Fetal Brain Injury 23. Infection, Inflammation and Brain Injury 24. Intracranial Hemorrhage 25. Ischemic Lesions of the Developing Brain SECTION V Perinatal Asphyxia 26. Pathophysiology of Asphyxia 27. Antenatal Prediction of Asphyxia 28. Intrapartum Monitoring for Asphyxia 29. Prediction of Asphyxia with Fetal Blood Gas Analysis 30. The Asphyxiated Newborn Infant 31. Neuroprotection of the Fetal and Neonatal Brain 32. Medico-legal Issues: The UK Perspective 33. Medico-legal Issues: The US Perspective SECTION VI Infection of the CNS 34. Toxoplasmosis 35. Viral Infections 36. Bacterial and Fungal Infections SECTION VII Metabolic Disorders 37. Prenatal Diagnosis of Inborn Errors of Metabolism 38. Inborn Errors of Metabolism, Postnatal Diagnosis and Management 39. Degenerative Disorders of the Infant CNS SECTION VIII Seizure Disorders 40. Seizure Disorders of the Neonate and Infant SECTION IX the Special Senses 41. Disorders of Vision 42. Disorders of Hearing SECTION X Disorders of the Nerve and Muscle 43. Disorders of the Spinal Cord, Cranial and Peripheral Nerves 44. Neuromuscular Disorders SECTION XI Hydrocephalus and Neurosurgery 45. Fetal Neurosurgical Interventions 46. Neonatal Hydrocephalus - Clinical Assessment and Non-Surgical Management 47. Neurosurgical Management of Hydrocephalus 48. Neurosurgical Management of NTD 49. Congenital Defects, Vascular Malformations and Other Lesions SECTION XII Epidemiology of Neurologic Disability 50. Epidemiology of Cerebral Palsy 51. Epidemiology of Mental Retardation SECTION XIII Ethical Dilemmas 52. Issues for the Obstetrician 53. Issues for the Neonatologist