Hematopathology

Key Features

Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification.

Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria.

Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each.

Details the latest insights on the molecular biology of benign and malignant hematologic disorders.

Features more than 1,100 high-quality color images that mirror the findings you encounter in practice.

Uses an easy-to-navigate, templated format with standard headings in each chapter.

Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis.

Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.

An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Contents

Part I: TECHNICAL ASPECTS 1. Processing of the Lymph Node Biopsy Specimen 2. Fine Needle Aspiration of Lymph Nodes 3. Collection, Processing, and Examination of Bone Marrow Specimens 4. Immunohistochemistry for the Hematopathology Laboratory 5. Flow Cytometry 6. Molecular Diagnosis in Hematopathology 7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them

Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES

8. Normal Lymphoid Organs and Tissues 9. The Reactive Lymphadenopathies 10. The Normal Bone Marrow 11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia 12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

Part III: LYMPHOID NEOPLASMS

13. Principles of Classification of Lymphoid Neoplasms

Section 1: Mature B-Cell Neoplasms

14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia 15. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia 16. Hairy Cell Leukemia 17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 18. Follicular Lymphoma 19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma 20. Primary Cutaneous B-Cell Lymphomas 21. Nodal Marginal Zone Lymphoma 22. Mantle Cell Lymphoma 23. Diffuse Large B-Cell Lymphoma 24. Burkitt Lymphoma and its Mimics 25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma 26. Plasma Cell Neoplasms 27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma 28. Classical Hodgkin's Lymphoma and Related Lesions 29. Virally Associated B-Cell Lymphoproliferative Disease

Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS

30. Virally Associated T-Cell and NK-Cell Neoplasms 31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations 32. T-Cell Prolymphocytic Leukemia 33. Adult T-Cell Leukemia/Lymphoma 34. Hepatosplenic T-Cell Lymphoma 35. Peripheral T-Cell Lymphoma, Not Otherwise Specified 36. Angioimmunoblastic T-Cell Lymphoma 37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative 38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas 39. Mycosis Fungoides and Sézary Syndrome 40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders 41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

Section 3: Precursor B- and T-Cell Neoplasms

42. Precursor B- and T-Cell Neoplasms 43. Acute Leukemias of Ambiguous Lineage

Part IV: MYELOID NEOPLASMS

44. Principles of Classification of Myeloid Neoplasms 45. The Myelodysplastic Syndromes 46. Acute Myeloid Leukemia 47. Myeloproliferative Neoplasms 48. Myelodysplastic/Myeloproliferative Neoplasms 49. Mastocytosis 50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2 51. Blastic Plasmacytoid Dendritic Cell Neoplasm

Part V: HISTIOCYTIC PROLIFERATIONS

52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow 53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Part VI: IMMUNODEFICIENCY DISORDERS

54. The Pathology of Primary Immunodeficiencies 55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder

Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA

56. Bone Marrow Evaluation for Lymphoma 57. Evaluation of the Bone Marrow After Therapy 58. Non-Hematopoietic Neoplasms of the Bone Marrow 59. Nonlymphoid Lesions of the Lymph Nodes 60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions 61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

Elaine Sarkin Jaffe, MD, Daniel A. Arber, MD, Elias Campo, MD, Leticia Quintanilla-Fend, MD, Attilio Orazi, MD, Lisa M. Rimsza, MD and Steven H. Swerdlow, MD