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Landmark Papers in Cardiovascular Medicine provides a thorough and wide-ranging analysis of core examples of novel research, clinical trials and seminal papers published in the medical literature that have paved the way for breakthroughs in the management of the entire spectrum of cardiovascular disease. These papers may have produced positive, negative or equivocal findings but are regarded by the experts as having either stimulated a paradigm shift in therapeutic strategy or been the catalyst for new and improved methods of research, diagnosis or drug development. Our aim is to provide both a benchmark and inspiration for future work in the field of cardiovascular medicine and also to give the reader an insight into the mechanics and infrastructure of how high-quality evidence-based medicine has been produced. Each trial summary is punctuated by sections on 'strengths and limitations', 'impact on the field', 'learning points' and 'further reading' suggestions that allow for a completely holistic analysis of the data. The experts also give their views on what research is currently underway, their hopes for the future and what advances they predict will occur in each subspecialty field of cardiovascular medicine, making this book essential reading for all those individuals with an interest in the field. Table of Contents 1: CORONARY HEART DISEASE ; 1. Epidemiology, Outcomes and Quality of Care ; 2. Lipids and Cardiovascular Disease ; 3. Physiology of Myocardial Ischaemia ; 4. Thrombosis, Haemostasis and Platelet Biology ; 5. Medical versus Invasive Management of Coronary Heart Disease ; 6. Percutaneous Coronary Intervention ; 7. Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft Surgery ; 2: CARDIAC ELECTROPHYSIOLOGY AND HEART RHYTHM DISTURBANCES ; 8. Epidemiology and Molecular Foundation ; 9. Atrial Fibrillation ; 10. Percutaneous Intervention ; 11. Anti-Arrhythmic Drug Therapy ; 3: HEART FAILURE ; 12. Epidemiology ; 13. Medical Management ; 14. Cardiac Resynchronisation Therapy ; 15. Non-Ischaemic Cardiomyopathy ; 16. Cardiac Failure and Transplantation ; 4: HYPERTENSION ; 17. Systemic Arterial Hypertension ; 18. Pulmonary Arterial Hypertension ; 5: VALVULAR HEART DISEASE ; 19. Epidemiology and Intervention ; 20. Endocarditis ; 6: CARDIAC IMAGING ; 21. Echocardiography ; 22. Cardiovascular Magnetic Resonance ; 23. Cardiac Computed Tomography ; 7: CONGENTIAL HEART DISEASE ; 24. Congenital Heart Disease ; 8: OBSTETRIC CARDIOLOGY ; 25. Obstetric Cardiology ; 9: CARDIAC REHABILITATION ; 26. Cardiac Rehabilitation