Neuroprotection in Critical Care and Perioperative Medicine

Neuroprotection is becoming an increasingly recognized and important part of critical care and perioperative medicine. As human beings survive increasingly severe life-threatening injuries and complex surgical interventions, it has become clear that neurologic injury and dysfunction is a primary driver of long-term outcome and disability. Neuroprotection is currently under-recognized as the primary objective in promoting recovery from life-threatening injuries, illnesses, and procedures.

To address this knowledge gap, Neuroprotection in Critical Care and Perioperative Medicine provides a concise review of the current state of the art of clinical care and research. Within the context of critical care, the specific topics covered will include the primary forms of brain injury on which neuroprotection research and intervention has traditionally focused, such as traumatic brain injury, cardiac arrest, acute ischemic stroke, and intracranial hemorrhage, as well as CNS injuries related to sepsis and acute respiratory distress syndrome, mechanical circulatory support, and premature birth. Within the context of perioperative care, the specific topics covered will include anesthetic and perioperative strategies to reduce brain injury from cardiac surgery, aortic surgery and endovascular repair, carotid endarterectomy, vascular and endovascular neurosurgery, and other major surgical procedures.

Contents

PROTECTION STRATEGIES
1. Physiologic Modulators of Neural Injury After Brain and Spinal Cord Injury
W. Dalton Dietrich
2. Pharmacologic Neuroprotection
Nino Stocchetti and Marco Carbonara
CLINIMETRICS OF NEUROPROTECTION
3. Imaging Assessment of Brain Injury
Matthew A. Warner, Carlos Marquez de la Plata, David S. Liebeskind, and Ramon Diaz-Arrastia
4. Tissue Biomarkers and Neuroprotection
Axel Petzold
5. Neurophysiological Monitoring and Neuroprotection
Aws Alawi, Michael Reznik, Jan Claassen
6. Neurological and Functional Outcomes Assessment
Suzan Uysal and Stephan A. Mayer
7. Assessment of Postoperative Cognitive Decline
Suzan Uysal and David L. Reich
NEUROPROTECTION IN CRITICAL CARE
8. Neuroprotection for Traumatic Brain Injury
Jonathan J. Ratcliff and David W. Wright
9. Neuroprotection for Cardiac Arrest
Joseph Pitcher and David B. Seder
10. Neuroprotection for Acute Ischemic Stroke
Diana Mayor and Michael Tymianski
11. Neuroprotection for Intracranial Hemorrhage
Julius Griauzde, Neeraj Chaudhary, Joseph J Gemmete, Aditya S Pandey, Guohua Xi
12. Neuroprotection for Mechanical Circulatory Support
Lauren E Dunn, Joshua Z Willey, Ronald M Lazar
13. Neuroprotection in Sepsis and Acute Respiratory Distress Syndrome
Neha S. Dangayach, Charles L Francoeur, Stephan A. Mayer, Tarek Sharshar
14. Neuroprotection for Premature Birth and Neonatal Brain Injury
Eugene Chang
15. Neuroprotection for Spinal Cord Injury
Christopher S. Ahuja and Michael Fehlings
PERI-OPERATIVE NEUROPROTECTION
16. Neuroprotection for Valvular and Coronary Bypass Surgery
Karsten Bartels G. Burkhard Mackensen
17. Neuroprotection for Aortic Surgery and Stenting
Jared W. Feinman and John G. Augoustides
18. Neuroprotection for Carotid Endarterectomy and Stenting
Zirka H. Anastasian and Eric J. Heyer
19. Neuroprotection for Vascular and Endovascular Neurosurgery
Travis R Ladner, Nishant G Kumar, Lucy He, J Mocco
20. Neuroprotection for Spine Surgery
Jess W. Brallier and Jonathan S. Gal
21. Neuroprotection for General, Orthopedic, Peripheral Vascular and ENT Surgery
Magdy Selim