Huntington Disease

Table of Contents:

Section 1 Basic Science
1. Genetics of Huntington disease
2. Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies

Section 2 Clinical Aspects
3. Epidemiology of Huntington disease
4. Statistical modelling of Huntington disease onset
5. The diagnosis and natural history of Huntington’s disease
6. Preclinical cognitive and behavioral changes in Huntington disease
7. Preclinical motor manifestations of Huntington disease
8. The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist’s role in assessment and counseling
9. Reproductive options for Huntington disease families
10. Genetic testing for Huntington disease

Section 3 Treatment of Huntington Disease
11. Medical treatment of behavioral manifestations of Huntington disease
12. Medical management of motor manifestations of Huntington disease
13. The role of rehabilitation therapy in Huntington disease
14. Contemporary health care for Huntington disease
15. The impact of Huntington disease on young people
16. Making a measurable difference in advanced Huntington disease care

Section 4 Experimental Therapeutics
17. New symptomatic therapies for Huntington disease
18. Motor outcome measures in Huntington disease clinical trials
19. Cognitive outcome measures in Huntington disease clinical drug trials

Section 5 Biomarkers
20. Structural imaging in premanifest and manifest Huntington disease
21. Functional imaging in Huntington disease