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Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. It is fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging. It covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments. It features new chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain. It provides practical advice on running an experiment. It includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience. It features full color throughout. Heidi Johansen-Berg (Author, Editor), Timothy E. J. Behrens (Editor) Reviews "A thorough and exciting review of the diffusion MRI techniques that are going to rewrite our knowledge of the long tract anatomy of the human brain. Extremely well written and illustrated." - Michael S. Gazzaniga, Director, Sage Center for the Study of Mind, University of California, Santa Barbara, USA "25 years after its debut, diffusion MRI today provides us with beautiful, marvelous images of connecting wires within the human brain, and this is achieved just by placing healthy subjects or patients in the middle of a strong magnet. How is this miracle possible? What could we expect from the knowledge of the brain connectome? This beautifully illustrated book addresses these questions with great clarity. The book is highly recommendable to all those who are interested in the links between brain structure and function." - Denis Le Bihan, Member of the Institut de France, Academy of Sciences; Director, NeuroSpin; CEA-Saclay Center, Gif-sur-Yvette, France "Unbelievable as it may seem, we know almost nothing about the real connectivity of the human cerebral cortex.What we think we know is mostly inferred from results obtained in the monkey.This book provides an exciting exploration of diffusion tensor imaging, a method that can start to close this gap.The editors, who are themselves pioneers in this field, have assembled authoritative chapters on the promises that lie ahead and the challenges that will be encountered." - Marsel Mesulam, Ruth and Evelyn Dunbar Professor of Neurology, Psychiatry and Psychology; Director, The Cognitive Neurology and Alzheimer's Disease Center (CNADC), Feinberg School of Medicine, Northwestern University, Chicago, USA