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This is the only complete advanced textbook that covers all major principles of neurochemistry and neurobiology. It is a classic text now in its 8th edition and is co-published with the American Society for Neurochemistry whose mission is to advance and promote cellular and molecular neuroscience knowledge around the world. The book's team of editors and chapter authors are among the world's leading neuroscientists. The new edition has a renewed focus on clinical applications so that students can better understand the molecular bases of human disease and how pharmacotherapies are developed. Edited by George Siegel, Loyola University, Chicago, IL, USA; R. Wayne Albers, National Institutes of Health, Bethesda MD, USA and Donald Price, The Johns Hopkins University School of Medicine, Baltimore MD; Scott Brady, University of Illinois, Chicago IL Table of Contents: Part I: Cellular Neurochemistry and Neural Membranes Neuronal Cell Biology Cell Membrane Structures and Functions Membrane Transport Electrical Excitability and Ion Channels Lipids The Cytoskeleton of Neurons and Glia Intracellular Trafficking Axonal Transport Cell Adhesion Molecules Myelin Structure and Biochemistry Energy Metabolism of the Brain PART II: Intercellular Signaling Synaptic Transmission and Cellular Signaling: An Overview Acetylcholine Catecholamines Serotonin Histamine Glutamate GABA Purinergic Systems Peptides PART III: Intracellular Signaling G Proteins Cyclic Nucleotides in the Nervous System Phosphoinositides Calcium Serine and Threonine Phosphorylation Tyrosine Phosphorylation Transcription Factors in the Central Nervous System PART IV: Growth, Development and Differentiation Development Growth Factors Stem Cells in the Nervous System Formation and maintenance of myelin Axonal Growth in the Adult Mammalian Nervous System PART V: Cell Injury and Inflammation Neuroimmunology Neuroinflammation Hypoxic'Ischemic Brain Injury and Oxidative Stress Lipid Mediators: Eicosanoids, Docosanoids, Platelet-Activating Factor and Inflammation Apoptosis and Necrosis PART VI: Inherited and Neurodegenerative Diseases Peripheral Neuropathy Diseases Involving Myelin The Epilepsies: Phenotype and Mechanisms Genetics of Neurodegenerative Diseases Disorders of Amino Acid Metabolism Diseases of Carbohydrate, Fatty Acid and Mitochondrial Metabolism, including Lysosomal and Peroxisomal Diseases Disorders of Muscle Excitability Motor Neuron Diseases Neurobiology of Alzheimer's Disease Neurodegenerative alpha-Synucleinopathies and Tauopathies Trinucleotide repeat diseases Neurotransmitters and Disorders of the Basal Ganglia Molecular Basis of Prion Diseases PART VII: Sensory Transduction Molecular Biology of Vision Molecular Biology of Olfaction and Taste Molecular Biology of Hearing and Balance Pain PART VIII: Neural Processing and Behavior Endocrine Effects on the Brain and Their Relationship to Behavior Learning and Memory Sleep The Neurochemistry of Schizophrenia Autism Neurobiology of Severe Mood and Anxiety Disorders Addiction