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An innovative, organ-specific text that blends basic science with the fundamentals of clinical medicine Part of the Human Organ Systems series, Renal: An Integrated Approach to Disease skillfully bridges the gap between the science and practice of medicine. This beautifully illustrated book seamlessly integrates the core elements of cell biology, anatomy, physiology, pharmacology, and pathology, with clinical medicine. It is the perfect companion for medical students transitioning to their clinical years, as well as practicing physicians who need a user-friendly update on the basic science underlying the practice of clinical medicine. Features and highlights include: Detailed learning objectives clearly state learning goals Core content emphasizes concepts and incorporates the latest developments in the field Beautifully illustrated with detailed legends to clarify important or difficult concepts Abundant clinical example boxes highlight the clinical implications of basic science Each chapter is accompanied by an annotated bibliography to provide an overview of the critical literature in the field A bulleted summary at the end of each chapter highlights the 'big picture' and facilitates preparation for standardized exams End-of-chapter case-based questions with detailed explanations reinforce important concepts and assess mastery of the material Medical students and residents will find Renal: An Integrated Approach to Disease an invaluable study guide for an organ-system based curriculum. The book also serves as an excellent primer for postgraduate residents entering a nephrology fellowship program. Paul G. Schmitz, M.D., FACP Professor of Internal Medicine Dept. of Nephrology Saint Louis University School of Medicine St. Louis, MO Table of contents Contributors Foreword Preface Acknowledgments Abbreviations Section I: Renal Anatomy 1. Normal Development and Congenital Anomalies, Paul G. Schmitz 2. Gross and Microscopic Anatomy with Functional Correlations, Paul G. Schmitz and Bahar Bastani Section II: Renal Physiology 3. Body Fluid Composition and Fluid Administration, Paul G. Schmitz 4. Glomerular Hemodynamics, Paul G. Schmitz 5. Principles of Renal Clearance, Paul G. Schmitz 6. Transport of Electrolytes and Water in the Proximal Tubule, Paul G. Schmitz 7. Transport of Electrolytes and Water in the Loop of Henle, Paul G. Schmitz 8. Transport of Electrolytes and Water in the Distal Tubule, Paul G. Schmitz 9. Renal Endocrinology, Paul G. Schmitz and Kevin J. Martin Section III: Electrolyte Disorders 10. Water Disorders, Paul G. Schmitz 11. Potassium Disorders, Paul G. Schmitz 12. Edema and Diuretic Use, Paul G. Schmitz Section IV: Acid-Base 13. Acid-Base Physiology, Paul G. Schmitz and Bahar Bastani 14. Acid-Base Disorders, Paul G. Schmitz and Bahar Bastani Section V: Kidney Disease 15. Approach to the Patient with Kidney and Urinary Tract Disease, Paul G. Schmitz 16. Glomerular Disease, Paul G. Schmitz 17. Tubulointerstitial Disease, Paul G. Schmitz Section VI: Renal Failure 18. Acute Kidney Injury, Paul G. Schmitz 19. Chronic Kidney Disease, Paul G. Schmitz, Kevin J. Martin, and Bahar Bastani Section VII: Miscellaneous Disorders 20. Hypertension, Paul G. Schmitz 21. Urologic Disorders, Paul G. Schmitz Answers to Questions Index