Ocular Pathology

Comprehensive, yet concise and clinically oriented, this new edition brings you the very latest advances of every aspect of ocular pathology. From discussions of molecular biology and genetics, to new sections on age-related macular degeneration and complications of refractive surgery, to revised chapters, the latest imaging modalities, and so much more, this 6th edition will surely keep you on top of your field. Complementing the text is a world-renowned collection of common and unusual ocular conditions and a DVD containing valuable educational tools. New to this edition Offers the expertise of a brand-new co-author, Joseph William Sassani, MD, MHA, who brings new insights to the latest pathologic findings. Discusses rapidly evolving subjects, including genetics and molecular biology, and addresses hot topics such as the role of the myocilin/TIGR gene in the development of glaucoma, the classification of orbital neoplasms, and many others to keep you on the cusp of today’s knowledge. Presents a new discussion on the pathobiology of ocular complications of diabetes mellitus, including diabetic macular edema and severity scales, the interventional clinical classification of diabetic retinopathy, and the role of VEGFF and other factors. Provides OCT, UBM, and MRI/CT images of key conditions, offering you a better visual correlation to pathological entities. Features entirely new sections on age-related macular degeneration and complications of refractive surgery to help you avoid complications and make the best informed decisions. Incorporates revisions of all chapters in fast changing fields such as classifications of soft tissue tumors and the modern developments of histopathological terminology and developments. Includes a bonus DVD that contains the entire textbook’s image library—downloadable for your use—and the Aperio System of virtual microscopy that allows you to zoom in and out when viewing the included digitized histopathology slides. By Myron Yanoff, MD, Myron Yanoff MD Professor and Chair Department of Ophthalmology Drexel University College of Medicine Adjunct Professor of Ophthalmology University of Pennsylvania Philadelphia, PA, USA and Joseph W. Sassani, MD, MHA, Professor of Ophthalmology and Pathology Chief of the VA Hospital, Department of Ophthalmology, Penn State Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA The Milton S. Hershey Medical Center Table of Contents: 1. BASIC PRINCIPLES OF PATHOLOGY Inflammation Immunobiology Cellular and Tissue Reactions 2. CONGENITAL ANOMALIES Phakamatoses (Disseminated Hereditary Hamartomas) Chromosomal Aberrations Infectious Embryopathy Drug Embryopathy Other Congenital Anomalies 3. NONGRANULOMATOUS INFLAMMATION: UVEITIS, ENDOPHTHALMITIS, PANOPHTHALMITIS, AND SEQUELAE Classification Suppurative Endophthalmitis and Panophthalmitis Nonsuppurative, Chronic Nongranulomatous Uveitis and Endophthalmitis Sequelae of Uveitis, Endophthalmitis, and Panophthalmitis End Stage of Diffuse Ocular Diseases 4. GRANULOMATOUS INFLAMMATION Introduction Post-Traumatic Nontraumatic Infectious Nontraumatic Noninfectious 5. SURGICAL AND NONSURGICAL TRAUMA Causes of Enucleation Normal Wound Healing Complications of Intraocular Surgery Complications of Neural Retinal Detachment and Vitreous Surgery Complications of Corneal Surgery Complications of Nonsurgical Trauma 6. SKIN AND LACRIMAL DRAINAGE SYSTEM SKIN Normal Anatomy Terminology Congenital Abnormalities Aging Inflammation Lid Manifestations of Systemic Dermatoses or Disease Cysts, Pseudoneoplasms, and Neoplasms LACRIMAL DRAINAGE SYSTEM Normal Anatomy Congenital Abnormalities Inflammation – Dacryocystitis Tumors 7. CONJUNCTIVA Normal Anatomy Congenital Anomalies Vascular Disorders Inflammation Injuries Conjunctival Manifestations of Systemic Disease Degenerations Cysts, Pseudoneoplasms, and Neoplasms   8. CORNEA AND SCLERA CORNEA Normal Anatomy Congenital Defects Inflammations – Nonulcerative Inflammations – Ulcerative Inflammations – Corneal Sequelae Injuries Degenerations Dystrophies Pigmentations SCLERA Congenital Anomalies Inflammations Injuries Tumors 9. UVEA Normal Anatomy Congenital and Developmental Defects Congenital and Developmental Defects of the Pigment Epithelium Inflammations Injuries Systemic Diseases Atrophies and Degenerations Dystrophies Tumors Uveal Edema 10. LENS Normal Anatomy General Information Congenital Anomalies Capsule (Epithelial Basement Membrane) Epithelium Cortex and Nucleus (Lens Cells or “Fibers”) Secondary Cataracts Complications of Cataracts Ectopic Lens 11. NEURAL (SENSORY) RETINA Normal Anatomy Congenital Anomalies Vascular Diseases Inflammations Injuries Degenerations Hereditary Primary Retinal Dystrophies Hereditary Secondary Retinal Dystrophies Systemic Diseases Involving the Retina Tumors Neural Retinal Detachment 12. VITREOUS Normal Anatomy Congenital Anomalies Inflammation Vitreous Adhesions Vitreous Opacities Vitreous Hemorrhage 13. OPTIC NERVE Normal Anatomy Congenital Defects and Anatomic Variations Optic Disc Edema Optic Neuritis Optic Atrophy   14. ORBIT Normal Anatomy Exophthalmos Developmental Abnormalities Orbital Inflammation Injuries Vascular Disease Ocular Muscle Involvement in Systemic Disease Neoplasms and Other Tumors   15. DIABETES MELLITUS Natural History Retinal Vasculature in Normals and Diabetics Conjunctiva and Cornea Lens Iris Ciliary Body and Choroid Neurosensory Retina Vitreous Optic Nerve 16. GLAUCOMA Normal Anatomy Introduction Normal Outflow Tissue Changes Caused by Elevated Intraocular Pressure 17. OCULAR MELANOTIC TUMORS Normal Anatomy Melanotic Tumors of Eyelids Melanotic Tumors of Conjunctiva Melanotic Tumors of Pigment Epithelium of Iris, Ciliary Body, and Retina Melanotic Tumors of the Uvea Melanotic Tumors of the Optic Disc Melanotic Tumors of the Orbit 18. RETINOBLASTOMA AND PSEUDOGLIOMA Retinoblastoma Pseudoglioma