Dermatologic Principles and Practice in Oncology

This is the first book to focus on frequent and frequently disabling side effects involving the skin, hair, and nails in cancer patients. It provides detailed descriptions of mechanism-of-action in all current oncology drugs and the clinical presentation and mechanisms underlying their dermatologic side effects, alongside carefully presented treatment recommendations, allowing physicians to significantly enhance their care of patients with cancer. Whereas existing oncology and dermatology textbooks only briefly deal with this topic, this resource offers dermatologists and other practitioners a focused perspective on cancer-related skin conditions. Table of Contents Section 1 Dermotology and Oncology 1 Epidemiology and Burden of Disease Beth McLellan and Mario E. Lacouture 2 The History of Supportive Oncodermatology Yevgeniy Balagula1, Steven T. Rosen and Mario E. Lacouture 3 Structure and Function of the Integumentary System and the Dermatology Lexicon Emmy Garber and Amit Garg 4 Types of dermatologic reactions Raed O. Alhusayen, Sandra R. Knowles and Neil H. Shear 5 Grading Dermatologic Adverse Events on Clinical Trials using CTCAE v4.0 Alice Chen, Asha Acharya and Ann Setser 6 Psychosocial Issues in Oncology: Clinical management of psychosocial distress, health-related quality of life and special considerations in dermatologic oncology Lynne I. Wagner and David Cella 7 Dermatopathology James L. Troy and Molly Hinshaw Section 2 8 Cancer-Related Dermatologic Disorders Cindy England Owen and Jeffrey P. Callen Section 3 Dermatologic Conditions During Cancer Therapy 9 ORAL MUCOSAL COMPLICATIONS OF CANCER THERAPY Stephen T. Sonis 10 Hair Disorders Associated with Anticancer Agents Caroline Yeager and Elise A. Olsen 11 NAIL ABNORMALITIES IN ONCOLOGY PRACTICE Robert Baran, Bernard Fouilloux and Caroline Robert 12 Pruritus Tejesh Patel and Gil Yosipovitch 13 Management Options for Hot Flashes in Cancer Patients Amanda R. Moraska and Charles L. Loprinzi Section 4 Skin toxicities due to chemotherapy 14 Alkylating agents (Busulfan, ThioTEPA, Mechlorethamine, Melphalan, Chlorambucil, cyclophosphamide, ifosfamide, carmustine, streptozocin, dacarbazine, temozolomide, etoposide,BCNU) Elisabeth Livingstone, Lisa Zimmer, Larissa Schöttler, Dirk Schadendorf 15 Antimetabolite Reactions (Methotrexate, pemetrexed, capecitabine, cytarabine, gemcitabine, 6MP, 6-TG, fludarabine, cladribine) Emily Y. Chu and Heidi H. Kong 16 Topoisomerase-interacting agents (irinotecan, topotecan, doxorubicin, daunorubicin,epirubicin, idarubicin, mitoxantrone, dactinomycin, etoposide, teniposide) Tomas Skacel, Roger von Moos and Reinhard Dummer 17 Epidermal Growth Factor Receptor Inhibitor Reactions Yevgeniy Balagula and Mario E. Lacouture 18 Small Molecule Kinase Inhibitors Caroline Robert, Vincent Sibaud and Christine Mateus 19 Antimicrotubule agents (Paclitaxel, docetaxel, albumin-bound paclitaxel, vincristine, vinblastine, vi-norelbine, estramustine) Claus Garbe 20 Histone Deacetylase Inhibitors (HDAC inhibitors) Proteasome inhibitors Demethylating Agents Arsenicals Retinoids Najla Al-Dawsari, Shannon Campbell and Francine Foss 21 Miscellaneous Reactions (L-Asparaginase, bleomycin, thalidomide, lenalidomide) Katharina C. Kaehler, Christine B. Boers-Doets, Mario E. Lacouture and Axel Hauschild 22 Skin toxicities due to biotherapy (Interferon-α2b, Interleukin-2) Axel Hauschild, Katharina Kaehler and Mario Lacouture 23 Monoclonal antibodies Caroline Robert 24 Endocrine Agents Katherine Szyfelbein and Mario Lacouture 25 Agents for the management of hematologic reactions: epotein alpha, darbopoetin, G-CSF, GM-CSF; oprelvekin; low molecular weight heparin; warfarin. Mee-young Lee and Caroline C. Kim 26 RDERMATOLOGICAL PRINCIPLES AND PRACTICE IN ONCOLOGY Rebecca Wong and Zahra Kassam 27 Hematopoietic stem cell transplantation and graft-versus-host disease Stephanie Hu and Jonathan Cotliar 28 Extravasation Reactions Seppo W. Langer 29 Topical Anticancer Therapies Patricia L. Myskowski 30 Life-threatening (Serious) Dermatologic Adverse Events Milan Anadkat 31 Dermatologic infections Yevgeniy Balagula, Mario E. Lacouture and James I. Ito Section 5 32 Late Dermatologic Conditions Jennifer Namchoi Section 6 Dermatologic Practice in Oncology 33 Management Algorithms for Dermatologic Adverse Events Alyx Rosen, Iris Amitay-Laish and Mario E. Lacouture 34 Dermatological therapeutics and formulations Judy H. Borovicka, Jennifer RS Gordon, Ann Cameron Haley and Dennis P. West 35 Dermatological Techniques and Procedures Kishwer Nehal, Erica Lee and Robert Eilers 36 Appearance-Related Concerns in the Cancer Patient Amy J. Derick